Medical Research
- Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.
- Longitudinal study of congenital melanocytic naevi reveals that final colour is determined by normal skin colour, and is unaltered by superficial removal techniques.
- Predictors of Health-related Quality of Life and Psychological Adjustment in Children and Adolescents With Congenital Melanocytic Nevi: Analysis of Parent Reports.
- MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children.
- Melanoma in congenital melanocytic naevi.
- Widespread dynamic and pleiotropic expression of the melanocortin-1-receptor (MC1R) system is conserved across chick, mouse and human embryonic development.
- The patterns of birthmarks suggest a novel population of melanocyte precursors arising around the time of gastrulation
- Melanoma in congenital melanocytic naevi
- MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children.
- This paper looks at whether infantile haemangiomas (strawberry birthmarks) are commoner in people with CMN which had been suggested in the past – it turns out that they aren’t.
- This collaborative paper with Klaus Busam’s group in New York shows that a particular pathology staining test can help work out if a nodule in a CMN is melanoma rather than a benign proliferative nodule.
- This paper shows that a particular genetic test on a biopsy from CNS (brain or spine) disease can help work out if it is melanoma rather than benign neurological disease.
- Growth and Hormonal Profiling in Children with Congenital Melanocytic Naevig
- Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling
- Classification of neurological abnormalities in children with congenital melanocytic naevus syndrome identifies MRI as the best predictor of clinical outcome
- Next-Generation Sequencing of Nevus Spilus-Type Congenital Melanocytic Nevus: Exquisite Genotype-Phenotype Correlation in Mosaic RASopathies
- Immunohistochemical and ultrastructural features of congenital melanocytic naevus cells support a stem cell phenotype
- Multiple Congenital Melanocytic Naevi and Neurocutaneous Melanosis are Caused by Post-Zygotic Mutations in Codon 61 of NRAS
- Germline Melanocortin-1-Receptor Genotype Is Associated with Severity of Cutaneous Phenotype in Congenital Melanocytic Nevi: A Role for MC1R in Human Fetal Development
- The face in congenital melanocytic nevus syndrome
- Neuropathology of neurocutaneous melanosis: histological foci of melanotic neurons and glia may be undetectable on MRI
- Satellite lesions in congenital melanocytic nevi – time for a change of name
- The role of surgery in the management of congenital melanocytic naevi in children: a perspective from Great Ormond Street Hospital
- Great Ormond Street Hospital for Children Registry for Congenital Melanocytic Naevi: prospective study 1988-2007. Part 2- Evaluation of treatments
- Great Ormond Street Hospital for Children Registry for Congenital Melanocytic Naevi: prospective study 1988-2007. Part 1 – epidemiology, phenotype and outcomes
- Complications of congenital melanocytic naevi in children: analysis of 16 years’ experience and clinical practice